run the in silico gene knockdown experiment on the given network model

knockdown {bnlearn}

R Documentation

run the in silico gene knockdown experiment on the given network model

Description

Usage

knockdown(bnlearn, geneNames);

Arguments

bnlearn

the trained network model object, which could be created by the bnlearn api or the GEARS::new. [as InsilicoPerturbationExperiment]

geneNames

a character vector of the gene id for run the knockdown experiment, one @T:SMRUCC.genomics.Analysis.BNLearn.Intervention.InterventionResult




        Details

        

        Authors

        biosystem

        Value

        a vector of the InterventionResult perturbation result: the WildtypeMeans is the wildtype expression value of each gene, the MutantMeans is the expression value of each gene after the gene has been knocked down, and the FoldChanges, PercentChanges, ZScores and IsSignificant data is the differential analysis result of the perturbation.
clr value class
InterventionResult

        Examples

        

        
        [Package bnlearn version 1.0.0.0 Index]